In the subgroup with large stones (5 to 10 mm), tamsulosin did increase passage and should be considered.Ĭopyright © 2015 American College of Emergency Physicians. We found no benefit overall of 0.4 mg of tamsulosin daily for patients with distal ureteric calculi less than or equal to 10 mm in terms of spontaneous passage, time to stone passage, pain, or analgesia requirements. Adverse events were generally mild and did not differ between groups. There was no difference in urologic interventions, time to self-reported stone passage, pain, or analgesia requirements. In a prespecified subgroup analysis of large stones (5 to 10 mm), 30 of 36 (83.3%) tamsulosin participants had stone passage compared with 25 of 41 (61.0%) with placebo, a difference of 22.4% (95% confidence interval 3.1% to 41.6%) and number needed to treat of 4.5. Of 316 patients who received CT at 28 days, stone passage occurred in 140 of 161 (87.0%) in the tamsulosin group and 127 of 155 (81.9%) with placebo, a difference of 5.0% (95% confidence interval -3.0% to 13.0%). The median stone size was 4.0 mm in the tamsulosin group and 3.7 mm in the placebo group. There were 403 patients randomized, 81.4% were men, and the median age was 46 years. The primary outcomes were stone expulsion on CT at 28 days and time to stone expulsion. Patients were allocated to 0.4 mg of tamsulosin or placebo daily for 28 days.
ARCUZ 2 WHEN TO USE TRIAL STONE TRIAL
This was a randomized, double-blind, placebo-controlled, multicenter trial of adult participants with calculus on computed tomography (CT). We assess the efficacy and safety of tamsulosin compared with placebo as medical expulsive therapy in patients with distal ureteric stones less than or equal to 10 mm in diameter.
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8 Department of Surgery, The Townsville Hospital, Townsville, Queensland, Australia School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia.7 Department of Emergency Medicine, Princess Alexandra Hospital, Brisbane, Queensland, Australia.6 School of Medicine, University of Queensland, Brisbane, Queensland, Australia Department of Emergency Medicine, Nambour General Hospital, Nambour, Queensland, Australia.it says you need to be a true hero to enter, i got no clue about that.
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gowing into it takes you to a very, very hard place, harder or eaiser depending on the level of stone.
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5 Gold Coast Health Service District (Gold Coast University Hospital and Robina Hospital, Griffith University, Bond University), Gold Coast, Queensland, Australia. The trial stones: you combine them with a stone of blessing, and that makes a trial gate.4 Department of Emergency Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.3 Department of Emergency Medicine, The Townsville Hospital, Townsville, Queensland, Australia.Electronic address: 2 School of Medicine, University of Queensland, Brisbane, Queensland, Australia Department of Emergency Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. 1 Department of Emergency Medicine, The Townsville Hospital, Townsville, Queensland, Australia School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia School of Medicine, University of Queensland, Brisbane, Queensland, Australia.